How do I know if I have Pretibial myxedema

It is usually asymptomatic and more of a cosmetic concern, but can be itchy or sore. Early lesions are bilateral, firm, non-pitting, asymmetrical plaques or nodules; they may coalesce to form scaly, thickened and hardened skin areas. Hair follicles are often prominent giving a peau d’orange (orange peel) texture.

How do you know if you have myxedema?

  1. decreased breathing (respiratory depression)
  2. lower than normal blood sodium levels.
  3. hypothermia (low body temperature)
  4. confusion or mental slowness.
  5. shock.
  6. low blood oxygen levels.
  7. high blood carbon dioxide levels.
  8. coma.

What does myxedema skin look like?

Generalized myxedema is a manifestation of severe hypothyroidism developing over an extended period of time causing skin that appears waxy, doughy, swollen (although non-pitting) and dry.

What percentage of Graves disease patients will have pretibial myxedema?

Pretibial myxedema used to occur in up to 5 percent of patients with Graves’ disease and 15 percent of patients with Graves’ disease and orbitopathy [2,3], but the incidence of pretibial myxedema has declined considerably, probably because the diagnosis of Graves’ hyperthyroidism is now established much earlier, and …

How does pretibial myxedema occur?

Pretibial myxedema (PTM) occurs as a result of the deposition of hyaluronic acid in the dermis and subcutis. The precise cause of this phenomenon remains uncertain.

How do I fix myxedema?

Treatment involves administering thyroid hormone replacement medication into a vein. Antibiotics, steroid treatment, and breathing support may be necessary also. A person may need breathing assistance, such as continuous positive airway pressure (CPAP) if carbon dioxide levels in the blood are very high.

Is Pretibial myxedema itchy?

It is most commonly found on the pretibial areas, the dorsum of the feet, or in sites of prior trauma. It is usually asymptomatic and more of a cosmetic concern, but can be itchy or sore.

What is the difference between Pretibial myxedema and myxedema?

In this latter sense, myxedema refers to deposition of mucopolysaccharides in the dermis, which results in swelling of the affected area. One manifestation of myxedema occurring in the lower limb is pretibial myxedema, a hallmark of Graves disease, an autoimmune form of hyperthyroidism.

Is Pretibial myxedema seen in hypothyroidism?

Pretibial myxedema (PM) is an infiltrative dermopathy which is seen in grave’s disease. It is also associated with hypothyroidism, but is infrequently seen in Hashimoto’s thyroiditis. Lesions are seen commonly over pretibial region as non-pitting oedema or with a plaque morphology.

Does Graves disease cause clubbing?

Thyroid acropachy is rare and occurs in less than 1% of patients with Graves’ disease. Thyroid acropachy consists of clubbing of the digits, swelling of the hands and feet, and periosteal proliferation of the distal long bones.

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What is Pretibial?

Medical Definition of pretibial : lying or occurring anterior to the tibia a pretibial skin rash.

Do you have hypothyroidism look at your hands?

Signs and symptoms of hypothyroidism can show up in the hands and nails. Hypothyroidism can cause dermatologic findings such as nail infection, vertical white ridges on the nails, nail splitting, brittle nails, slow nail growth, and nails lifting up.

What can untreated hypothyroidism lead to?

Over time, untreated hypothyroidism can cause a number of health problems, such as obesity, joint pain, infertility and heart disease.

What Graves dermopathy looks like?

Rarely, people with Graves’ disease develop Graves’ dermopathy, a skin condition characterized by red, swollen skin, usually on the shins and tops of the feet. The texture of the affected skin may be similar to that of an orange peel. Doctors may also refer to the condition as pretibial myxedema.

What does methimazole do to the body?

Methimazole can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.

What does thyroid rash look like?

Hives in thyroid disease are similar to hives from other causes. You may have patchy areas of swelling or welts, called wheals. 2 They may appear on your chest, back, neck, face, or buttocks. Sometimes hives affect the arms or legs.

Do you get a rash with Graves disease?

The dermopathy of Graves’ disease is a rare, painless, reddish lumpy skin rash that of Graves’ disease is an autoimmune process. It is caused by thyroid-stimulating antibodies which bind to and activate the thyrotropin receptor on thyroid cells. Graves’ disease can run in families.

At what age is Graves disease usually diagnosed?

Graves’ disease usually affects people between ages 30 and 50, but can occur at any age. The disease is seven to eight times more common in women than men. A person’s chance of developing Graves’ disease increases if other family members have the disease.

What does hyperthyroidism do to your skin?

Hyperthyroidism results in an increase in the body’s metabolic rate, which characterised by: Flushing of the face and hands. Smooth, moist and warm skin. Fine, soft and thinned scalp hair.

When should I suspect myxedema coma?

Patients with myxedema coma are generally severely ill, with significant hypothermia and depressed mental status. A medical emergency, myxedema coma requires immediate attention. If the diagnosis is suspected, immediate management is necessary before confirming the diagnosis due to the high associated mortality rate.

Why does hypothyroidism cause puffy face?

Hypothyroidism is underactivity of the thyroid gland that leads to inadequate production of thyroid hormones and a slowing of vital body functions. Facial expressions become dull, the voice is hoarse, speech is slow, eyelids droop, and the eyes and face become puffy.

What triggers myxedema coma?

Myxedema coma occurs when the body’s compensatory responses to hypothyroidism are overwhelmed by a precipitating factor such as infection. A common misconception is that a patient must be comatose to be diagnosed with myxedema coma.

Is Pretibial myxedema bilateral?

Bilateral erythematous infiltrative plaques in the pretibial areas. Early lesions are bilateral, firm, nonpitting, asymmetrical plaques or nodules. Hair follicles are sometimes prominent, giving a peau d’orange texture. Areas of nonpitting edema may develop.

Does Graves disease cause Pretibial myxedema?

Pretibial myxedema or localized myxedema or thyroid dermopathy is an autoimmune manifestation of Graves’ disease. It also occasionally occurs in Hashimoto’s thyroiditis. Lesions of thyroid dermopathy are usually asymptomatic and have only cosmetic importance.

What is periorbital myxedema?

Periorbital myxedema is one the most challenging symptoms for patients with Graves’ eye disease (GED). The treatment of this condition is complex and often unsatisfactory. This case demonstrates the use of intralesional hyaluronidase to treat cosmetically concerning periorbital myxedema.

Can overactive thyroid cause leg swelling?

Bilateral leg edema has been found in patients with various forms of hyperthyroidism. This is a first description of unilateral leg edema and so whether this manifestation is specific to Graves’ disease or may appear with other forms of hyperthyroidism is currently unclear.

What causes thyroid Acropachy?

The exact cause is unknown, but it is thought to be caused by stimulating auto-antibodies that are implicated in the pathophysiology of Graves’ thyrotoxicosis. There is no effective treatment for acropachy.

Can hypothyroidism cause finger clubbing?

Thyroid acropachy is an extreme manifestation of autoimmune thyroid disease. It presents with digital clubbing, swelling of digits and toes, and periosteal reaction of extremity bones. It is almost always associated with ophthalmopathy and thyroid dermopathy.

What is a myxedema coma?

Myxedema coma is defined as severe hypothyroidism leading to decreased mental status, hypothermia, and other symptoms related to slowing of function in multiple organs. It is a medical emergency with a high mortality rate.

How common is thyroid acropachy?

Thyroid acropachy is a rare extra-thyroid manifestation of autoimmune thyroid disease. It affects about 0.3% of patients with Graves’ disease and often occurs in euthyroid and hypothyroid patients within weeks to many years after treatment of original thyrotoxicosis [1], [2].

How is Pretibial Myxoedema treated?

Surgical treatment should be avoided because scarring may aggravate the dermopathy, and benefits are equivocal. Local application of corticosteroids remains the mainstay of treatment. Compression wraps or stockings that provide 20-40 mm Hg of pressure can be useful as an adjunctive therapy.