What is precedex used for

Dexmedetomidine is a sedative that is used to sedate a patient who is under intensive medical care and needs a mechanical ventilator (breathing machine).

What type of drug is Precedex?

Precedex is a prescription medicine used as a sedative before and/or during surgical and other procedures. Precedex may be used alone or with other medications. Precedex belongs to a class of drugs called Sedatives.

Why is Precedex bad?

Because Precedex decreases sympathetic nervous system activity, hypotension and/or bradycardia may be expected to be more pronounced in patients with hypovolemia, diabetes mellitus, or chronic hypertension and in elderly patients.

What are the indications for Precedex?

The FDA-approved indications for dexmedetomidine are sedation of intubated and mechanically ventilated patients in the intensive care unit (ICU) and peri-procedural (or peri-operative) sedation of non-intubated patients.

Does Precedex help with anxiety?

Opioids, benzodiazepines, propofol, antipsychotics and dexmedetomidine (Precedex) are frequently used in the intensive care unit (ICU) to manage pain, anxiety, agitation and delirium, and to facilitate procedures such as mechanical ventilation.

Why can precedex only be used for 24 hours?

The FDA states that if used for >24 hours, dexmedetomidine can cause tolerance and tachyphylaxis. The FDA also states that prolonged exposure can cause a dose-related increase in adverse events such as acute respiratory distress syndrome (ARDS), respiratory failure and agitation.

Is precedex better than propofol?

Conclusions: For ICU patient sedation, dexmedetomidine may offer advantages over propofol in terms of decrease in the length of ICU stay and the risk of delirium. However, transient hypertension may occur when dexmedetomidine is administered with a loading dose or at high infusion rates.

Does precedex treat pain?

A large number of clinical studies have shown that intraoperative dexmedetomidine can significantly reduce postoperative pain intensity and opioid use, and the incidence of opioid-related adverse events.

Can you take propofol and precedex together?

Using propofol together with dexmedetomidine may have increased effects on breathing, heart rate, blood pressure, and sedation. You will be monitored closely by your surgical team during anesthesia, and the doses of each medication adjusted accordingly.

Why is precedex used in ICU?

Background. Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration of mechanical ventilation and delirium among patients in the intensive care unit (ICU).

Article first time published on askingthelot.com/what-is-precedex-used-for/

How does precedex affect the heart?

Patients who receive dexmedetomidine and develop a greater than 30% decrease in heart rate may be at high risk for severe bradycardia leading to pulseless electrical activity. We urge caution when using dexmedetomidine, especially in patients with significant cardiac disease.

Does precedex affect blood pressure?

Dexmedetomidine administered in high concentrations may cause systemic and pulmonary hypertension because of direct peripheral vascular effects or may compromise myocardial function and blood pressure.

What can you use instead of propofol?

Fospropofol (Lusedra®) is a water-soluble, non-pyrogenic, iso-osmotic pro-drug sedative-hypnotic agent that is metabolized to propofol, and, if dosed appropriately, may be an alternate drug selection to propofol in some patients undergoing monitored anesthesia care (MAC).

Does Precedex put you to sleep?

Dexmedetomidine is a clinically effective and safe sedative for the highly selected critically ill patients without endotracheal tube and mechanical ventilation in the ICU to increases total sleep time and improve sleep efficiency.

Can you become addicted to Precedex?

9.3 Dependence The dependence potential of Precedex has not been studied in humans.

Does Precedex slow breathing?

Precedex can interact with other drugs that can cause drowsiness or slowed breathing, leading to dangerous side effects or death.

Is propofol stronger than midazolam?

We conclude that propofol is a sedative agent with the same safety, higher clinical effectiveness, and a better cost-benefit ratio than midazolam in the continuous sedation of critically ill patients.

What is sedation?

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. Examples of drugs which can be used for sedation include isoflurane, diethyl ether, propofol, etomidate, ketamine, pentobarbital, lorazepam and midazolam.

Does propofol or precedex cause more hypotension?

In a 2011 summary of Precedex safety data from RCTs analyzed by the the EMA (European FDA), the drug was found to be discontinued about 2% of the time for bradycardia and 1.5% of the time for hypotension, slightly more than propofol (0.4% brady and 1.1% hypotension) and significantly more than midazolam (0.3% and 0.3%) …

Can nurses administer precedex?

Registered nurses must complete a moderate sedation inservice and maintain yearly competency. Sedation nurses may then administer midazolam, Fentanyl, Demerol and morphine, under the physician’s direction.

How long does precedex stay in your system?

The terminal elimination half-life of intravenous dexmedetomidine ranged 2.1 to 3.1 hours in healthy adults and 2.2 to 3.7 hours in ICU patients.

What should I start with precedex?

Loading dose: Recommend starting infusion at 0.4 mcg/kg/hour WITHOUT loading dose in most patients as this has decreased the incidence of bradycardia. Precedex must be diluted in 0.9% sodium chloride solution to achieve required concentration (4 mcg/mL) prior to administration.

Is versed the same as propofol?

Midazolam is a benzodiazepine and Propofol is an I.V. sedative-hypnotic. Brand names for midazolam include Versed. Brand names for Propofol include Diprivan, Anesthesia S/I-40, and Anesthesia S/I-40A.

What are side effects of propofol?

Tell your doctor right away if you have chest pain or discomfort, confusion, dark-colored urine, dizziness, drowsiness, lightheadedness, fainting, fever, muscle cramps, spasms, pain, or stiffness, nausea, right upper abdominal or stomach pain and fullness, slow or irregular heartbeat, trouble breathing, stomach cramps, …

What is the generic name for precedex?

What Is Precedex? Precedex (dexmedetomidine hydrochloride) is an alpha2-adrenergic agonist with sedative properties used for short-term intravenous sedation.

Where does precedex work in the brain?

Dexmedetomidine works at ╬▒2-receptors both peripherally and centrally; however, the sedative and anxiolytic effects of the drug are mediated through stimulation of central ╬▒2-receptors. Activation of these receptors attenuates central nervous system excitation, especially in the locus coeruleus.

Does propofol have analgesic properties?

Although propofol is a good sedative and amnestic drug, it does not have analgesic properties. Too often, in our opinion, patients receive propofol, at a time when an analgesic would serve them better.

How does propofol work in the body?

Like most intravenous anesthetics, Propofol works by increasing GABA-mediated inhibatory tone in the CNS. Propofol decreases the rate of dissociation of the GABA from the receptor, thereby increasing the duration of the GABA-activated opening of the chloride channel with resulting hyperpolarization of cell membranes.

Does precedex cause rebound tachycardia?

A discontinuation syndrome manifest as rebound agitation, hypertension, and tachycardia is recognized after prolonged clonidine infusion and has occasionally been reported with dexmedetomidine. When stopping the drug, patients should be monitored for symptoms and if apparent should prompt a more gradual dose reduction.

Does precedex cause heart block?

One of the most serious adverse effects of dexmedetomidine is cardiac arrest. Some cases demonstrating such an arrest due to the indiscriminate use of this drug were recently reported.

Why does precedex cause Brady?

Activation of the receptors in the brain and spinal cord inhibits neuronal firing, causing hypotension, bradycardia, sedation, and analgesia.